Pressure regulates immune-cell function

Heparanase regulates immune cell functions

Immune cells can modify surrounding extracellular matrices by producing matrix degradation enzymes. Heparan sulfate proteoglycans, a major component of basement membrane, play a key role in the self-assembly, insolubility, and barrier properties of the matrix. Some immune cell subsets express heparanase, the sole mammalian endoglycosidase that cleaves heparan sulfate chains and thereby potentia...

Immune Cell Function Assay

Description of Procedure or Service Populations Interventions Comparators Outcomes Individuals:  With a solid organ transplant Interventions of interest are:  Immune cell function assay Comparators of interest are:  Standard monitoring of immunosuppression Relevant outcomes include:  Overall survival  Test accuracy  Other test performance measures  Morbid events Individuals:  With a hem...

Myelin regulates immune cell adhesion and motility.

The etiology of multiple sclerosis (MS) has not been fully elucidated, however evidence supports an autoimmune disease model notable for the infiltration of pro-inflammatory immune cells into sites of active demyelination and axonal injury. Previous findings demonstrate that neutralization of Nogo, a protein originally identified as a myelin-associated inhibitor (MAI) of axon regeneration, amel...

Lymphopenia-Induced T Cell Proliferation Innate Immune Cell CD45 Regulates

Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis.

Homeostasis of the gastrointestinal (GI) tract is controlled by complex interactions between epithelial and immune cells and the resident microbiota. Here, we studied the role of Wnt signaling in GI homeostasis using Disheveled 1 knockout (Dvl1-/-) mice, which display an increase in whole gut transit time. This phenotype is associated with a reduction and mislocalization of Paneth cells and an ...